The Size factor (long small caps / short large caps) was Artemis' worst performer in May at -12.8%, its worst month of 2026. Reason: in a risk-off tape liquidity flees to the majors, and large caps HYPE (+70%) and NEAR (+67%) squeezed the short (large-cap) book while the small-cap longs lagged. That's a flight-to-quality signal - so trade WITH it, not against it. Long the large-cap quality that absorbs the bid: BTC is ~76% of Artemis' market factor and the structural beta anchor; BNB was +11.5% in May, a rare large cap that held green. Short the mid/small DeFi beta that breaks down first: JUP faltered as a Momentum long (-24%), CRV is thin small-cap beta. Confirms it: BTC dominance keeps grinding up and alt/large ratios keep bleeding. Kills it: a decisive risk-on rotation where small caps outrun majors and the Size premium reasserts (still +8.7% annualized long-run). Source: Artemis Crypto Factor Model, June 2026 - https://www.artemis.ai/artemis/article/325711237350457010